Abstract
Oxidative stress is a deleterious impact, plays a key role in diabetic complications. The current work was designed to assess the hypoglycemic action of either nanoresveratrol (nano-Resv) or chromium picolinate (CrPic) and their effects in attenuating hyperglycemic stress induced in diabetic rats. Induction of diabetes in rats was performed by injection of intraperitoneal single dose of streptozotocin (STZ) (40mg/Kg body weight). Nano-Resv (20mg/Kg b.w.) or CrPic (80 ae g/Kg b.w.) were administered orally to diabetic rats for thirty successive days. The results demonstrated that both nano-Resv and CrPic markedly down regulated the serum glucose content and increased the level of serum insulin in diabetic animals. The study also showed that treatment by both agents, significantly modulated the increase in the serum oxidative stress biomarker, nitric oxide (NO), and the decreases in the serum antioxidant markers, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S transferase (GST) and reduced glutathione GSH). Conclusion: The current study proved that both nano-Resv and CrPic have a potential impact in modulating hyperglycemia-induced oxidative stress and may candidate as useful drugs in controlling diabetes related oxidative stress.