Abstract
The present study investigated the structural, morphological, thermal, and pharmacological properties of aurin tri-carboxylic acid triammonium salt (AAS) complexed with Au(III), Ta(V), Nb(V), Se(IV), and Te(IV) ions. The formed complexes were characterized by spectroscopic and physicochemical techniques, such as CHN elemental analysis, magnetic moment, conductivity, FTIR, H-1 NMR, and UV-visible spectroscopies; XRD; SEM; TEM; and thermogravimetry. The analytical and spectral data suggest that Ta(V), Nb(V), Se(IV), and Te(IV) ions formed octahedral complexes,where Au(III) ion formed square planar complex. The biological activity of the formed complexes was evaluated using two human cancer cell lines and four microbes. The Kirby-Bauer disc diffusion and MTT- based assay methods were used for antibacterial screening and cytotoxicity towards MCF-7 and HepG2 cell lines, respectively. Investigation on cytotoxic activity showed that the complexation with Au(III) ions increased the cytotoxic activity of AAS by 57% towards HepG2 cells and by 45% towards MCF-7 cells. Investigation on antibacterial activity showed that the Te(IV) complex had a remarkable profile towards Gram-negative bacteria. (C) 2021 Elsevier B.V. All rights reserved.