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Au(III)-catalyzed regio- and stereoselective tandem synthesis of oxazolo fused naphthyridines and isoquinolines from o-alkynylaldehydes
Journal article   Peer reviewed

Au(III)-catalyzed regio- and stereoselective tandem synthesis of oxazolo fused naphthyridines and isoquinolines from o-alkynylaldehydes

Rajeev Ranjan Jha, Abhinandan Kumar Danodia, Sushil Kumar and Akhilesh Kumar Verma
Tetrahedron letters, Vol.55(3), pp.610-615
15/01/2014
DOI: https://doi.org/10.1016/j.tetlet.2013.11.072

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
An efficient tandem approach for the regio- and stereoselective synthesis of oxazolo-fused naphthyridines 3a-g, 3i-l and isoquinolines 3h, 3m via the reaction of o-alkynylaldehydes 1a-i with chiral amino alcohols 2a-c under mild reaction conditions is described. The stereochemistry and structures of the products were assigned via NOESY and X-ray crystallographic studies. (C) 2013 Elsevier Ltd. All rights reserved.

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