Abstract
To evaluate the effect of olive leaves extract (OLE) on type 2 diabetes mellitus (T2DM) induced by streptozotocin (STZ) in rats, male rats were allocated into four groups; normal control, diabetic control (45 mg/kg STZ), normal rats treated orally with OLE (17.8 mg/kg b.wt.) and diabetic rats treated with OLE. The changes in glucose level, kidney and liver function were investigated. OLE kept glucose level close to normal. There was a significant change between total protein and total albumin as the extract was found to keep them near normal level. Creatinine, urea, uric acid and liver function levels were very high in diabetic group. OLE significantly improved the levels of urea, creatinine, uric acid and kept liver function markers in normal range on treated diabetic rats. The present study submits that, OLE could be used to prevent T2DM complications such as nephropathy and liver damage through enhancing glycemic state.