BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts

T. M Kohl; C Hellinger; F Ahmed; C Buske; W Hiddemann; S. K Bohlander; K Spiekermann

doi:10.1038/sj.leu.2404776

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BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts

Journal article

Peer reviewed

BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts

T. M Kohl, C Hellinger, F Ahmed, C Buske, W Hiddemann, S. K Bohlander and K Spiekermann

Leukemia, Vol.21(8), pp.1763-1772

01/08/2007

DOI: https://doi.org/10.1038/sj.leu.2404776

PMID: 17554384

Abstract

Biological and medical sciences

Hematologic and hematopoietic diseases

Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis

Medical sciences

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Title: BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts
Creators - without role: T. M Kohl - Clinical Cooperative Group 'Leukemia', Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, GSF-National Research Center for Environment and Health, Munich, Germany
C Hellinger - Clinical Cooperative Group 'Leukemia', Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, GSF-National Research Center for Environment and Health, Munich, Germany
F Ahmed - Clinical Cooperative Group 'Leukemia', Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, GSF-National Research Center for Environment and Health, Munich, Germany
C Buske - Clinical Cooperative Group 'Leukemia', Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, GSF-National Research Center for Environment and Health, Munich, Germany
W Hiddemann - Clinical Cooperative Group 'Leukemia', Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, GSF-National Research Center for Environment and Health, Munich, Germany
S. K Bohlander - Clinical Cooperative Group 'Leukemia', Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, GSF-National Research Center for Environment and Health, Munich, Germany
K Spiekermann - Clinical Cooperative Group 'Leukemia', Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, GSF-National Research Center for Environment and Health, Munich, Germany
Publication Details: Leukemia, Vol.21(8), pp.1763-1772
Publisher: Nature Publishing
Identifiers: 9934739908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article