Abstract
This study aims to achieve effects of improved hydrophilicity and microorganism inhibition, which are rarely simultaneously present in wound dressings. Cotton gauzes were modified using the grafting of a polymer-based beta-cyclodextrin. After optimizing the grafting conditions, the untreated and modified cellulosic samples were principally characterized using FT-IR spectroscopy, TGA/DTA analysis, in vitro drug release, and wettability measurements. In light of desired characteristics of wound dressings, the effectiveness of procedures was evaluated. It was found that contact angles for cotton gauzes decreased after functionalization, which means that hydrophilicity was proven to become excellent. A successful Methylene Blue complexation was confirmed through measure of the dyebath exhaustion using UV-spectrophotometry. Then, during Methylen Blue release test, we reported an initial burst release of active ingredient over 7 h, followed by zero-order release. The treatment effect on antimicrobial activity was investigated by growth inhibition, which was proven against Staphylococcus aureus and Escherichia coli.