Abstract
For centuries, countries in the Mediterranean and all of Europe have employed olive leaves in traditional medicine. This substance has antioxidative stress and anti-inflammatory properties. In this work, the potential protective effects of olive extract were investigated in relation to the histochemical and histological alterations in the skin of rats following exposure to cyclophosphamide. Thirty-six mature male albino rats served as the subjects for the current study. There were three equal groups formed from them. The control group received no medical treatment. Animals in the cyclophosphamide group were given 100 mg kg BW one dose of cyclophosphamide intraperitoneally. Rats in the third group received daily dosages of 15 mg/kg body weight of olive extract for one week prior to and one week following the injection of cyclophosphamide. Various stains were used to examine the histopathological as well as histo-chemical alterations in skin tissue. Cyclophosphamide-exposed rats' skin underwent a number of histological and histochemical alterations. Administering Olive Extract helped to improve these changes. The current study demonstrated olive extract's curative and preventive effects on albino rats' skin against cyclophosphamide-induced skin damage.