Abstract
Twenty-six benzimidazole derivatives were synthesized and they showed potent α-glucosidase inhibitory activities. [Display omitted]
•Synthesis of Benzimidazole Derivatives novel 1–26.•In vitro α-glucosidase inhibitory activity.•Some of compounds are more active than standard drug.•Structure–activity relationship has been established.•Docking study.
Newly synthesized benzimidazole hydrazone derivatives 1–26 were evaluated for their α-glucosidase inhibitory activity. Compounds 1–26 exhibited varying degrees of yeast α-glucosidase inhibitory activity with IC50 values between 8.40±0.76 and 179.71±1.11μM when compared with standard acarbose. In this assay, seven compounds that showed highest inhibitory effects than the rest of benzimidazole series were identified. All the synthesized compounds were characterized by different spectroscopic methods adequately. We further evaluated the interaction of the active compounds with enzyme with the help of docking studies.