Abstract
Carbonic anhydrase inhibitory activity of benzimidazole derivatives 1-24 has been evaluated. Compounds 22 (IC50 = 7.47 +/- 0.39 mu M), 21 (IC50 = 10.31 +/- 0.11 mu M), 20 (IC50 = 23.1 +/- 1.78 mu M), 12 (IC50 = 12.16 +/- 0.10 mu M), 11 (IC50 = 12. 81 +/- 0.29 mu M), and 15 (IC50 = 13.18 +/- 0.37 mu M) showed carbonic anhydrase inhibitory activity, and compared with the standard acetozolamide (IC50 = 0.31 +/- 0.0006 mu M). All the compounds were characterized by spectroscopic techniques.