Abstract
In the present study we have evaluated the antigenotoxic effects of Farnesol (FL) a 15-carbon isoprenoid alcohol against benzo (a) pyrene [B(a)P] (125mgkg-1.b.wt oral) induced toxicity. B(a)P administration lead to significant induction in Cytochrome P450 (CYP) content and aryl hydrocarbon hydrolase (AHH) activity (p0.001), DNA strand breaks and DNA adducts (p0.001) formation. FL was shown to suppress the activities of both CYP and AHH (p0.005) in modulator groups. FL pretreatment significantly (p0.001) restored depleted levels of reduced glutathione (GSH), quinone reductase (QR) and glutathione -S-transferase (GST). A simultaneous significant and at both the doses reduction was seen in DNA strand breaks and in in-vivo DNA adducts formation (p0.005), which gives some insight on restoration of DNA integrity. The results support the protective nature of FL. Hence present data supports FL as a future drug to preclude B (a) P induced toxicity.