Abstract
Abstract
Stable Fmoc-, Boc-, and Alloc-benzotriazoles react with various
amino acids including unprotected serine and glutamic acid, in the
presence of triethylamine at 20 ˚C as reagents
to introduce α-amino protecting groups to afford Fmoc-,
Boc-, and Alloc-protected amino acids (77-94%)
free of dipeptide and tripeptide impurities. Fmoc-, and Alloc-Gly-Gly-OH
dipeptides were prepared in 90% yields by N-acylation of
glycylglycine with Fmoc- and Alloc-benzotriazoles in the presence
of triethylamine. Synthesized N-protected amino acids were greater
than 99% pure, analyzed by HPLC.