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Benzotriazole-assisted solid-phase assembly of Leu-enkephalin, amyloid beta segment 34-42, and other "difficult" peptide sequences
Journal article   Peer reviewed

Benzotriazole-assisted solid-phase assembly of Leu-enkephalin, amyloid beta segment 34-42, and other "difficult" peptide sequences

Alan R Katritzky, Danniebelle N Haase, Jodie V Johnson and Alfred Chung
Journal of organic chemistry, Vol.74(5), pp.2028-2032
06/03/2009
DOI: https://doi.org/10.1021/jo8026214
PMID: 19196166

Abstract

Amyloid beta-Peptides - chemical synthesis Amyloid beta-Peptides - chemistry Enkephalin, Leucine - chemical synthesis Enkephalin, Leucine - chemistry Microwaves Molecular Structure Oligopeptides - chemical synthesis Oligopeptides - chemistry Peptide Fragments - chemical synthesis Peptide Fragments - chemistry Triazoles - chemistry
Microwave-assisted solid-phase syntheses of six "difficult" peptides, H-VVSVV-NH(2) (3), H-VVVSVV-NH(2) (4), H-VIVIG-OH (5), H-TVTVTV-NH(2) (6), H-VKDGYI-NH(2) (7), and H-VKDVYI-NH(2) (8), were achieved utilizing N-(Fmoc-alpha-aminoacyl)benzotriazoles. Extension to the syntheses of Leu-enkephalin (9) and amyloid-beta (34-42) (10) demonstrates that this strategy comprises an efficient route to new and known "difficult" peptides.

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