Abstract
Mono- and difluoro-β-amino esters were synthesized
via Reformatsky reaction of fluorinated ethyl bromoacetates with
N-(
α-aminoalkyl)benzotriazoles. Secondary and tertiary amines are easily formed, but primary amines can only be made in the difluorinated case. This approach has led to the first synthesis of di- and tetrafluorinated bis(β-amino esters).
Mono- and difluoro-β-amino esters were synthesized
via Reformatsky reaction of fluorinated ethyl bromoacetates with
N-(α-aminoalkyl)benzotriazoles.