Abstract
Current study resolved poor oral bioavailability issues of cefixime through fabrication of freeze dried binary solid lipid nano particles (SLNs). Nano formulation fabricated via hot melt encapsulation method was optimized using numerous formulation variables. Optimized nano formulation (CFX-4) was subjected to in vitro characterization along with determination of encapsulation efficiency and drug loading capacity. Scanning electron microscopy represented spherical shaped particles. Differential scanning calorimetry and X-ray powder diffraction revealed reduction in drug's crystallinity. Drug-excepient compatibility was established through Fourier transform infrared spectroscopy. In vitro studies favored sustained drug release with increased drug payload. Stability studies exposed that refrigerated temperature imparts maximum stability to binary SLNs. In vivo studies revealed desired enhancement in oral bioavailability of nano formulation compared to the marketed product (Cefiget (R)). Presented investigations established the dominance of binary SLNs for oral bioavailability improvement with sustained drug release features for their successful use as an advanced drug delivery system for hydrophobic drugs.