Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

Shao-Chun Wang; Huang-Chun Lien; Weiya Xia; I.-Fen Chen; Hui-Wen Lo; Zhiqin Wang; Mohamed Ali-Seyed; Dung-Fang Lee; Geoffrey Bartholomeusz; Fu Ou-Yang; Dipak K. Giri; Mien-Chie Hung

doi:10.1016/j.ccr.2004.07.012

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Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

Journal article

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Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

Shao-Chun Wang, Huang-Chun Lien, Weiya Xia, I.-Fen Chen, Hui-Wen Lo, Zhiqin Wang, Mohamed Ali-Seyed, Dung-Fang Lee, Geoffrey Bartholomeusz, Fu Ou-Yang, …

Cancer cell, Vol.6(3), pp.251-261

01/09/2004

DOI: https://doi.org/10.1016/j.ccr.2004.07.012

PMID: 15380516

Abstract

Pathological expression of human ErbB-2 protein, also known as HER-2, is common in many types of cancer. ErbB-2 is a member of the EGF receptor tyrosine kinase family and has been rigorously studied as a signaling molecule on the cell membrane. Here, we report that ErbB-2 is also expressed in the nucleus in cultured cells as well as primary tumor tissues. Nuclear ErbB-2 was found to associate with multiple genomic targets in vivo, including the cyclooxygenase enzyme COX-2 gene promoter. ErbB-2 forms a complex at a specific nucleotide sequence of the COX-2 promoter and is able to stimulate its transcription. This study demonstrates the presence of ErbB-2 in the nucleus and identifies the function of ErbB-2 as a transcriptional regulator.

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Title: Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2
Creators - without role: Shao-Chun Wang - The University of Texas MD Anderson Cancer Center
Huang-Chun Lien - The University of Texas MD Anderson Cancer Center
Weiya Xia - The University of Texas MD Anderson Cancer Center
I.-Fen Chen - The University of Texas MD Anderson Cancer Center
Hui-Wen Lo - The University of Texas MD Anderson Cancer Center
Zhiqin Wang - The University of Texas MD Anderson Cancer Center
Mohamed Ali-Seyed - The University of Texas MD Anderson Cancer Center
Dung-Fang Lee - The University of Texas MD Anderson Cancer Center
Geoffrey Bartholomeusz - The University of Texas MD Anderson Cancer Center
Fu Ou-Yang - The University of Texas MD Anderson Cancer Center
Dipak K. Giri - The University of Texas MD Anderson Cancer Center
Mien-Chie Hung - The University of Texas MD Anderson Cancer Center
Publication Details: Cancer cell, Vol.6(3), pp.251-261
Publisher: Elsevier Inc
Identifiers: 9933617508331
Academic Unit: University of Tabuk
Language: English
Resource Type: Journal article