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Bioactive saponins from Acacia tenuifolia from the suriname rainforest
Journal article   Peer reviewed

Bioactive saponins from Acacia tenuifolia from the suriname rainforest

Youngwan Seo, Jeannine Hoch, Maged Abdel-Kader, S Malone, I Derveld, Hermus Adams, M C M Werkhoven, Jan H Wisse, Stephen W Mamber, James M Dalton, …
Journal of natural products (Washington, D.C.), Vol.65(2), pp.170-174
01/02/2002
DOI: https://doi.org/10.1021/np0103620
PMID: 11858750

Abstract

Acacia - chemistry Animals Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Drug Screening Assays, Antitumor Female Gas Chromatography-Mass Spectrometry Humans Inhibitory Concentration 50 Lung Neoplasms Mice Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid - analogs & derivatives Ovarian Neoplasms Plants, Medicinal - chemistry Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Stereoisomerism Suriname Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Tumor Cells, Cultured - drug effects Yeasts - drug effects
Bioassay-guided fractionation of the MeOH extract of Acacia tenuifolia using the engineered yeast strains 1138, 1140, 1353, and Sc7 as the bioassay tool resulted in the isolation of the three new saponins 3, 5, and 6 and the three known saponins 1, 2, and 4. The structures of the new compounds were established on the basis of HRMS, 1D and 2D NMR spectral data on the intact saponins, and GC-MS analyses of the sugars. Compounds 1,2 and 5,6 showed cytotoxicity against mammalian cell lines.

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