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Bioavailability of indenolol by nasal and intravenous routes
Journal article

Bioavailability of indenolol by nasal and intravenous routes

S A Babhair and M Tariq
Research communications in chemical pathology and pharmacology, Vol.59(1), pp.137-140
01/1988
PMID: 2895489

Abstract

Administration, Intranasal Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - pharmacokinetics Animals Biological Availability Indenes - administration & dosage Indenes - pharmacokinetics Infusions, Intravenous Propanolamines - administration & dosage Propanolamines - pharmacokinetics Rats
The blood levels of indenolol were determined in rats following nasal and intravenous administration of 5 mg/kg body weight of the drug. The results indicate that the peak drug levels reach within 10 minutes of nasal administration. The areas under the curve for nasal and intravenous routes were found to be 65.67 (ng x hr)/ml and 65.32 (ng x hr)/ml respectively. The results suggest that nasal route may be of practical value for the administration of indenolol.

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