Abstract
Among 35 different species comprising genus Fagonia; arabica is one of the most important species claimed to possess many medicinal properties. Present work intends to contribute towards validation of hepatoprotective efficacy associated with Fagonia arabica leaves using Carbon tetrachloride hepatotoxicity model. Biochemical and histological alterations were assessed and observed in livers of male albino rats independently and co-treated with various doses of dried leaf powder of Fagonia arabica and carbon tetrachloride. Two different doses of Fagonia arabica dried leaf powder were used viz. 250 mg/Kg BW, and 500 mg/kg BW against intraperitonial dose of 3ml/kg BW CCL4. Assessment was carried biochemically as well as with histology. Biochemical results of alterations observed in AST, ALT and ALP as well as total serum bilirubin and total serum protein were statistically analyzed and are presented in tabular as well as graphical form. Histological alterations were observed in and presented as microphotographs.