Abstract
Patulin mycotoxin on some biochemical parameters and histological changes on male rats' liver and effect of crude venom extracted from jelly fish Cassiopea Andromeda as a treatment. 50 Inbreeding weanling white male wistar lewis rats were divided randomly into 5 groups. Control group was gavage fed daily with distilled water; three treated groups were gavage fed daily dose with Patulin (0.2 mg/kg b.w.) for one, two and three weeks respectively. The last group was treated by Patulin for one week then injected intraperitoneally with single dose of crude venom (1.78 mg/20 g b.w.) for 24 hours according to LD50. Level of (AST) and (GGT) were increased significantly in serum of all treated groups compared with control group but level of (ALT) was increased significantly in treated group after one week only. Although the concentration of (TNF-alpha) was increased significantly and gradually in all treated groups, the concentration of ferritin was decreased significantly in treated three after three weeks only. Histopathological changes of rat liver coincided with biochemical changes. In conclusion, oral exposures of Patulin indicate that hepatic alteration was produced in manner related to dose duration and crude venom may used as new therapeutic approach to detoxify hepatocytes from Patulin. [Nagwa M. El-Sawi, Hanaa M. Gashlan, Sabry H. H. Younes, Rehab F. Al-Massabi and S. Shaker. Biochemical and histological studies on the effect of the Patulin mycotoxin on male rats' liver and treatment by crude venom extracted from jelly fish. Life Sci J 2012; 9(4): 1143-1153]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 171