Abstract
Distinct morphological MgO nanoparticles (MgONPs) were synthesized using biomasses ofSaussurea costusroots. The biomass of two varieties ofSaussurea costus(Qustal hindi and Qustal bahri) were used in the green synthesis of MgONPs. The physical and chemical features of nanoparticles were confirmed by spectroscopic and microscopic techniques. The surface morphology of the obtained nanoparticles was detected at different magnifications by SEM and TEM microscopy and the size of nanoparticles were found to be 30 and 34 nm for Qustal hindi and Qustal bahri, respectively. The antimicrobial activity of the prepared MgONPs was screened against six pathogenic strains. The synthesized nanoparticles by Qustal bahri biomass exerted significant inhibition zones 15, 16, 18, 17, 14, and 10 mm againstE.coli,P.aeruginosa,C.tropicalisandC.glabrata,S.aureusandB.subtilisas compared to those from Qustal hindi 12, 8 and 17 mm againstB.subtilis,E.coliandC.tropicalis, respectively. MgONPs showed a potential cytotoxicity effect against MCF-7 breast cancer cell lines. Cellular investigations of MgONPs revealed that the prepared nanoparticles by Qustal bahri exhibited high cytotoxicity against MCF-7 cancer cell lines. IC(50)values in MCF-7 cells were found to be 67.3% and 52.1% for MgONPs ofSaussurea costusbiomasses, respectively. Also, the photocatalytic activity of MgONPs of eachSaussurea costusvariety was comparatively studied. They exhibited an enhanced photocatalytic degradation of methylene blue after UV irradiation for 1 h as 92% and 59% for those prepared by Qustal bahri and Qustal hindi, respectively. Outcome of results revealed that the biosynthesized MgONPs showed promising biomedical potentials.