Abstract
Some (E)-4-(arylideneamino)-3-(1-(4-isobutylphenyl)ethyl)-1H-1,2,4-triazole-5(4H)-thiones (2a2e) were synthesized and evaluated as anti-inflammatory and analgesic agents. Compounds 2a-2e were synthesized from thiocarbohydrazide reacted with ibuprofen (2-(4-isobutylphenyl)propanoic acid) to formed 4-amino-3-(1-(4-isobutylphenyl)ethyl)-1H-1,2,4-triazole-5(4H)-thione (1). Compound 1 was refluxed with different aromatic aldehydes to form the title compounds or Schiff's Bases (2a-2e). All the synthesized compounds were identified by analytical techniques such as infrared (IR), proton nuclear magnetic resonance (1HNMR), and mass (Ms) spectral analysis. The result showed that compound 2d was showed significant anti-inflammatory and analgesic activity at 200 mg/kg dose compared to ibuprofen (200 mg/kg) as an anti-inflammatory drug and aspirin (200 mg/kg) as an analgesic drug. nas (2a-2e) y evaluadas como agentes antiinflamatorios y analgesicos. Los compuestos 2a-2e se sintetizaron a partir de tiocarbohidrazida reaccionada con ibuprofeno (acido 2- (4-isobutilfenil) propanoico) para formar 4-amino-3- (1- (4-isobutilfenil) etil) -1H-1,2,4-triazol -5 (4H) -tiona (1). El compuesto 1 se calento a reflujo con diferentes aldehidos aromaticos para formar los compuestos del titulo o bases de Schiff (2a-2e). Todos los compuestos de protones (1HNMR) y analisis espectral de masas (Ms). El resultado mostro que el compuesto 2d mostro una actividad antiinflamatoria y analgesica significativa a una dosis de 200 mg/kg en comparacion con el ibuprofeno