Biological interpretation of genome-wide association studies using predicted gene functions

Tune H. Pers; Juha M. Karjalainen; Yingleong Chan; Harm-Jan Westra; Andrew R. Wood; Jian Yang; Julian C. Lui; Sailaja Vedantam; Stefan Gustafsson; Tonu Esko; Tim Frayling; Elizabeth K. Speliotes; Michael Boehnke; Soumya Raychaudhuri; Rudolf S. N. Fehrmann; Joel N. Hirschhorn; Lude Franke; Genetic Invest ANthropometric Trai; Panos Deloukas

doi:10.1038/ncomms6890

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Biological interpretation of genome-wide association studies using predicted gene functions

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Biological interpretation of genome-wide association studies using predicted gene functions

Tune H. Pers, Juha M. Karjalainen, Yingleong Chan, Harm-Jan Westra, Andrew R. Wood, Jian Yang, Julian C. Lui, Sailaja Vedantam, Stefan Gustafsson, Tonu Esko, …

Nature communications, Vol.6(1), pp.5890-5890

19/01/2015

DOI: https://doi.org/10.1038/ncomms6890

PMCID: PMC4420238

PMID: 25597830

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.

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Title: Biological interpretation of genome-wide association studies using predicted gene functions
Creators - without role: Tune H. Pers - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Juha M. Karjalainen - University Medical Center Groningen
Yingleong Chan - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Harm-Jan Westra - Brigham and Women's Hospital
Andrew R. Wood - University of Exeter
Jian Yang - University of Queensland
Julian C. Lui - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Sailaja Vedantam - Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA 02115 USA
Stefan Gustafsson - Science for Life Laboratory
Tonu Esko - Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA 02115 USA
Tim Frayling
Elizabeth K. Speliotes - University of Michigan–Ann Arbor
Michael Boehnke - University of Michigan–Ann Arbor
Soumya Raychaudhuri - Brigham and Women's Hospital
Rudolf S. N. Fehrmann - University Medical Center Groningen
Joel N. Hirschhorn - Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA 02115 USA
Lude Franke - University Medical Center Groningen
Genetic Invest ANthropometric Trai
Panos Deloukas - King Abdulaziz University
Publication Details: Nature communications, Vol.6(1), pp.5890-5890
Publisher: NATURE PORTFOLIO
Number of pages: 9
Grant note: Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH Danish Council for Independent Research Medical Sciences (FSS) The Alfred Benzon Foundation G1001799; MR/K013351/1; MR/N01104X/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 259867 / European Community's Health Seventh Framework Programme (FP7) R190-2014-3904 / Lundbeck Foundation; Lundbeckfonden 916-10135; 917-14374 / Netherlands Organization for Scientific Research; Netherlands Organization for Scientific Research (NWO) Pers Group / NNF Center for Basic Metabolic Research; Novo Nordisk Foundation MR/K006584/1; MR/K013351/1; G1001799; MR/N01104X/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) NF-SI-0514-10027; NF-SI-0611-10219; NF-SI-0513-10059; NF-SI-0611-10170 / National Institute for Health Research; National Institute for Health Research (NIHR) CZB/4/672 / Chief Scientist Office 92519031 / Horizon Breakthrough grant from the Netherlands Genomics Initiative 2R01DK075787 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
Identifiers: 9934112908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article