Abstract
A new library of 2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethyl aryl ether derivatives (1 - 2 3) were synthesized and characterized by EI-MS and H-1 NMR, and screened for their alpha-amylase inhibitory activity. Out of twenty-three derivatives, two molecules 19 (IC50 = 0.38 +/- 0.82 mu M) and 23 (IC50 = 1.66 +/- 0.14 mu M), showed excellent activity whereas the remaining compounds, except 10 and 17, showed good to moderate inhibition in the range of IC50 = 1.77-2.98 mM when compared with the standard acarbose (IC50 = 1.66 +/- 0.1 mu M). A plausible structure-activity relationship has also been presented. In addition, in silico studies was carried out in order to rationalize the binding interaction of compounds with the active site of enzyme. (C) 2017 Elsevier Inc. All rights reserved.