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Biomimetic artificial ion channels based on beta-cyclodextrin
Journal article   Peer reviewed

Biomimetic artificial ion channels based on beta-cyclodextrin

Yassine El Ghoul, Ruddy Renia, Ibrahima Faye, Soumassoudrane Rassou, Nezha Badi, Véronique Bennevault-Celton, Cécile Huin and Philippe Guégan
Chemical communications (Cambridge, England), Vol.49(99), pp.11647-11649
01/01/2013
PMID: 24185371

Abstract

Chemical Physics Physics
Star polymers based on β-cyclodextrin were synthesized by a “click-chemistry” process and characterized by NMR, SEC and BLM. The resulting triazole functional groups create, at a specific pH range, electrostatic hindrance between pores inserted in lipid bilayers, preventing their aggregation, allowing formation of well-defined isolated unitary pores and mimicking biological natural channels.

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