Abstract
Tissue engineering is the immense area of research in recent years because of its vast potential in the repair or replacement of impaired tissues and organs. Bone is a nanomaterial composed of organic (collagen) and inorganic (mainly nano-hydroxyapatite) components, with a hierarchical structure ranging from nanoscale to macroscale. The bone disorder has been increasing and the goal is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. In this review biopolymeric nanocomposites provide a closer structural support approximation to native bone architecture for the cells and regulate cell proliferation, differentiation, and migration, which results in bone regeneration. Furthermore, there are some new challenges about the future research on the application of biopolymeric nanocomposites as scaffolds in the bone regeneration.
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