Abstract
In the current study, silver nanoparticles (AgNPs) were biosynthesised by microwave irradiation using Azadirachta indica. The formation of AgNPs was confirmed by surface plasmon resonance (SPR) band at 408 nm at UV-visible spectroscopy due to reduction of silver metal into (AgNPs) and further confirmed its particles in nano range. Nine different smart-gel hand wash were prepared by dispersing (AgNPs) in the HPMC and/or Pluronic F-127 polymers. The prepared smart gel hand wash was optimized based on pH, viscosity, spreadability, foamability, clarity. The optimized hand wash (NH5) had pH (6.6 ± 0.33), viscosity (66 ± 0.77, cp), spreadability (24.34 g-cm/s), foamability (100 mL). The optimized hand wash (NH5) showed a superior efficacy against pathogenic organisms in comparison to germ protection based marketed hand wash.