Abstract
Magnesium fluoride nanoparticles (denoted as “MgF-NPs”) has raised great attention in recent years because of their wide utilization in biomedical studies. However, little is known about the anticandidal activity of MgF-NPs against opportunistic oral pathogen C. albicans. Thus, the study was designed to investigate the antibiofilm activity of MgF-NPs against C. albicans 077 and their possible mechanism. MgF-NPs were prepared employing co-precipitation method using Withania somnifera leave extract as a biotemplate and stabilizer. The structural properties of the resultant surface modified MgF-NPs were investigated. It was remarkable that MgF-NPs showed the promising anticandidal in dose- and time-dependent manners. The data taken together conclude that MgF-NPs bear the potential of its applications in oral health and disease management.