Abstract
The micro-emulgel (MEG) loaded with natural plant extracts can be a promising innovative technique for cosmetology as the use of plant-based phytochemicals is gaining popularity day by day in the field. So, the present study was meant to formulate, characterize, and evaluate plant extract-based (seeds of Carthamus tinctorius, CT) polyphenol-loaded MEG. Assessment of the plant extract for antioxidant potential was made by DPPH and reducing power assay, total phenolic and flavonoid contents, tyrosinase inhibition potential, polyphenolic profiling by HPLC and was subjected to formulate a stable MEG system; further assessed by sta-bility studies of three months by zeta analysis (zeta sizing and potential), polydispersity index and release of phytoconstituents using static Franz-diffusion cell. Results revealed that CT extract is constituted of several polyphenols with high antioxidant and tyrosinase inhibitory potential. Moreover, the developed micro -emulsion is stable at various storage conditions with promising zeta size, zeta potential, and PDI values of 216.6 nm,-18 mV, and 0.442, respectively. 86.64% release from micro-emulsion was observed in comparison to 47.60% release from MEG. Conclusively, CT-based polyphenol-loaded stable MEG could be potentially employed as an improved vehicle for cosmeceutical purposes than conventional formulations.(c) 2022 SAAB. Published by Elsevier B.V. All rights reserved.