Abstract
The biotransformation of beta-estradiol (1,3,5-estratriene-3,17,beta-diols) by Bacillus subtillus resulted in four metabolites which were (1) 3,5-estratriene-3-ol-17-one, (2) 1,3,5-estratriene-3,16,17-triol, (3) 1,3,5,7-estratetra-ene-3-ol-17-one and (4) 1,3,5,6, estratetra-ene-3-ol-17-one. The structures were elucidated on the basis of spectroscopic techniques. Compound 3 showed good inhibitory activity against lipoxygenase enzyme.