Abstract
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare tumor type. This tumor closely resembles conventional papillary thyroid carcinoma and exhibits a solid spindle cell component, which is biphasic in appearance. The distinction of this low-grade tumor from other aggressive malignant neoplasms is important for clinical and therapeutic management. Here we present the case of a 19-year-old female who was diagnosed with a biphasic TL-LGNPPA. We also summarize the clinicopathological features, differential diagnosis, and clinical management of TL-LGNPPA with a spindle cell component.