Abstract
Antiepileptic drugs therapy are associated with myriad adverse effects. Some of antiepileptic drugs (AEDs) inhibit sodium channels that may cause dysrhythmia and hemodynamic instability if administered in too high dose.
We describe a patient with wide complex tachycardia likely secondary to medical management of status epilepticus specifically secondary to sodium channels blockade that successfully managed with supportive care and one session of hemodialysis.
In this case report, we discuss the successful management of the first reported combination of AEDs (Phenytoin and lacosamide) toxicity using supportive care and extracorporeal removal.
•Phenytoin and Lacosamide are sodium channels blockade.•Sodium channels blockade toxicity can lead to lethal ventricular arrhythmias and hemodynamic instability.•Extracorporeal removal of phenytoin and lacosamide can restore patient's rhythm and hemodynamic stability.