Abstract
The incorporation of textile technology and medical science has emerged into a new field known as medical textiles. Here, we formulated zinc oxide nanoparticles from B. serrata resins (BS-ZnONPs) and coated it on cotton fabrics for antibacterial and wound healing applications against the nosocomial pathogens. The synthesized BS-ZnONPs were characterized by UV-spectrophotometer, transmission electron microscope (TEM), and Fourier transform infra-red (FT-IR) analyses. The BS-ZnONPs were coated on the cotton fabrics and the same was confirmed by the scanning electron microscope (SEM) and energy-dispersive X-ray (EDX) studies. The antibacterial property of BS-ZnONPs-coated fabrics was examined against nosocomial pathogens, i.e., Klebsiella pneumoniae, Acinetobacter baumanii, Psuedomonas aeruginosa, Escherichia coli, Klebsiella oxytoca, and Staphylococcus aureus. The findings of characterization studies such as UV, TEM, FT-IR, SEM, and EDX revealed the development of BS-ZnONPs. The fabricated BS-ZnONPs treatment at various doses, i.e., 5-30 mu G/mL did not show any cytotoxicity to the L929 cells. The BS-ZnONPs demonstrated the considerable wound healing activity. The synthesized BS-ZnONPs and its coated cotton fabrics remarkably inhibited the growth of nosocomial pathogens such as K.pneumoniae, A.baumanii, P.aeruginosa, E.coli, K.oxytoca, and S.aureus. Our findings from the current study proved that the B. serrata is a good source of ZnONPs. The synthesized BS-ZnONPs and its treated cotton fabrics could be a promising antibacterial agent for the prevention of nosocomial infection.