Abstract
Ligninolytic enzymes are potential candidates in whitening cosmetics because of their high melanin decolorization potential. Lignin peroxidase (LiP) owns a special place in dermatology and cosmetology industries among ligninolytic enzymes due to its comparatively high redox potential than other enzymes. The unpurified LiPs after fungal fermentation are commonly studied in cosmetics formulations due to difficulties in enzyme purification. The deconstruction potential of LiP could be attributed to the versatility of substrates, including both non-phenolic and phenolic compounds and xenobiotics. The exploration of ligninolytic enzymes for potential biotechnological applications has commonly been reported over the years. This review aimed to summarize the futuristic applications and current functionalities of ligninolytic enzymes in modern cosmetics formulations as a skin-lightening agent through melanin decolorization applications. Studies suggest high throughput applications of LiP in the cosmetic sector, where it has the potential to replace hydroquinone and other skin-lightening agents whose safety has resulted in controversies. Moreover, pigmentation disorders such as hyperpigmentation could be treated in a sustainable manner using such enzyme-based approaches.
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