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Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo
Journal article   Peer reviewed

Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo

Sarita Saraswati and S S Agrawal
Cancer letters, Vol.332(1), pp.83-93
10/05/2013
DOI: https://doi.org/10.1016/j.canlet.2013.01.012
PMID: 23348691

Abstract

Angiogenesis Inhibitors - isolation & purification Angiogenesis Inhibitors - pharmacology Animals Carcinoma, Ehrlich Tumor - blood supply Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - pathology Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Chemotaxis - drug effects Cytokines - metabolism Dose-Response Relationship, Drug Female Gene Expression Regulation Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - enzymology Humans Male Mice Neovascularization, Physiologic - drug effects Nitric Oxide - metabolism Phosphorylation Plants, Medicinal Protein Kinase Inhibitors - isolation & purification Protein Kinase Inhibitors - pharmacology Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Signal Transduction - drug effects Strychnine - analogs & derivatives Strychnine - isolation & purification Strychnine - pharmacology Strychnos nux-vomica - chemistry Time Factors Tissue Culture Techniques Tumor Burden - drug effects Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism

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