Abstract
•Synthesis of novel series of benzoxazine derivatives and their Cu(II) complexes.•Tested against six bacterial and three fungal species.•Complexes showed good antimicrobial activity as compared with their ligands.•The molecular docking with 4GQQ and 5cdp proteins.•Reduction activity shown by the Vib, Vic and Vid complexes.
A novel series of benzoxazine derivatives have been synthesized via microwave assistance and used as ligands for the synthesis of their Cu(II) complexes using the same benign method. Synthesized ligands as well as complexes were characterized using NMR, LCMS, and FT-IR analytical tools. The crystalline nature of complexes has been analyzed by powder XRD. These complexes have been tested against six bacterial and three fungal species for their antimicrobial evaluation. Complexes have shown good antimicrobial activity against human pathogens as compared with their ligands, and varied with different pathogens. The molecular docking study against 4GQQ and 5cdp proteins with synthesized complexes was performed to see the necessary interactions responsible for anti-bacterial activity. The docking analysis of the Vid and Via complexes have supported the antibacterial activity exhibiting high GSC score and area obtained through PatchDoc server. The reduction activity shown by the Vib, Vic and Vid complexes inferred about their utility in catalytically process in industries.