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C-acylation of 2-methylfuran and thiophene using N-acylbenzotriazoles
Journal article   Peer reviewed

C-acylation of 2-methylfuran and thiophene using N-acylbenzotriazoles

A R Katritzky, K Suzuki and S K Singh
Croatica chemica acta, Vol.77(1-2), pp.175-178
01/05/2004

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
Reactions of 2-methylfuran and thiophene with readily available N-acylbenzotriazoles (RCOBt, where R = 4-tolyl, 4-methoxyphenyl, benzyl, 4-nitrophenyl, 4-diethylaminophenyl, 2-pyridyl and 1-naphthyl) in the presence of TiCl4 or ZnBr2 produced 2-methyl-4-acylfurans 2a-e and 2-acylthiophenes 3a-f in average yields of 54% and 75%, respectively. Literature yields for the preparation of the same compounds are significantly lower.

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