Abstract
C-reactive protein ultrasensitive (CRPus) is a member of very old and very conserved pentraxines family. It is characterized by homopentameric structure. It is considered as a crucial endogen peptide in evaluation of cardiovascular diseases risk. Seriques values of this marker of inflammation depend of several risk factors of coronary heart diseases (age, sex, diabetes, obesity, high blood pressure arterial, hyperlipidemia, smoking and family history). In this present study, we investigated the variation of CRPus in 96 patients with coronary heart diseases and 50 healthy controls of Tunisian population. CRPus have been measured by immunonephelemetric method (BNII- Behring). Our results have shown that the rates of CRPus obtained for healthy controls compared to patients are in order of 4.7 +/- 2.43 mg/l vs. 5.4 +/- 2.08 mg/l in diabetics; 3.69 +/- 3 mg/l vs. 5.8 +/- 1.43 mg/l in smokers; 4.7 +/- 1.98 mg/l vs. 5.89 +/- 2.43 mg/l in hypertense; 3.36 +/- 1.52 mg/l vs. 5.69 +/- 1.32 mg/l in hyperlipidemics; 4.24 +/- 1.2 mg/l vs. 8.29 +/- 3.2 mg/l in family history; 3.96 +/- 1.67 mg/l vs. 5.06 +/- 3.04 mg/l in hyperhomocysteinemics; 4.34 +/- 1.43 mg/l vs. 6.36 +/- 3.02 mg/l in Apo A1; 3.59 +/- 3.3 mg/l vs. 6.21 +/- 3.55 mg/l in Apo B and 4.13 +/- 2.05 mg/l vs. 6.7 +/- 2.8 mg/l in Lp a. Seriques values of CRPus increased considerably with accumulation of more risk factors. The rate of CRPus is in order 10.83 +/- 0.98 mg/l in patients with six risk factors. (C) 2010 Elsevier Masson SAS. All rights reserved.