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C-(α-d-Glucopyranosyl)-phenyldiazomethanes—irreversible inhibitors of α-glucosidase
Journal article   Peer reviewed

C-(α-d-Glucopyranosyl)-phenyldiazomethanes—irreversible inhibitors of α-glucosidase

Yiqun Geng, Amit Kumar, Hassan M. Faidallah, Hassan A. Albar, Ibrahim A. Mhkalid and Richard R. Schmidt
Bioorganic & medicinal chemistry, Vol.21(16), pp.4793-4802
15/08/2013
DOI: https://doi.org/10.1016/j.bmc.2013.05.055
PMID: 23806834

Abstract

Carbohydrate Diazo compounds Irreversible inhibition Synthesis α-Glucosidase
Several C-(α-d-glucopyranosyl)-phenyldiazomethanes, with different substituent groups at the para-position of the phenyl ring, were prepared. The stabilities of these diazo compounds were investigated through NMR and UV monitoring. The para-cyano substituted diazo compound was found to be stable in neutral media (pH 7.0 buffer) and could be isolated. Inhibitory activity investigations indicated that this compound is an irreversible inhibitor against α-glucosidase from Saccharomyces cerevisiae.

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