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C15 WHEN MICROBES ATTACK: HOST-PATHOGEN INTERACTIONS: Protection Against Viral Pneumonia Following Inhalation Of Synergistic Tlr Agonists Is Not Mediated By Induction Of Type I Interferons
Journal article   Peer reviewed

C15 WHEN MICROBES ATTACK: HOST-PATHOGEN INTERACTIONS: Protection Against Viral Pneumonia Following Inhalation Of Synergistic Tlr Agonists Is Not Mediated By Induction Of Type I Interferons

S Wali, Y Wang, M Leiva-Juarez, V Kulkarni, S Sunkesula, S Batres, D Goldblatt, J Flores, M Tuvim and S Evans
American journal of respiratory and critical care medicine, Vol.195
01/01/2017

Abstract

Hypotheses Interferon Pneumonia Viral infections Viruses
Toll-like receptors (TLRs) play crucial roles in innate immune responses to viral pathogens, and TLR-mediated virus detection is well established to often induce type I IFN production from lung epithelial cells, the principal target cell of many respiratory viruses. Methods: Primary mouse tracheal epithelial cells (mTECs) were treated with Pam2-ODN (or sham) prior to infection with influenza A or Sendai virus, then protein levels of type I IFN were assessed by ELISA.

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