Abstract
Methods: In this prospective observational study, adult patients admitted to the ICUs of King Abdulaziz Medical City-Riyadh (Center A) and King Fahad Medical City-Riyadh (Center B) between 2012 and 2016 and had Candida growth were assessed by two intensivists for the diagnosis of invasive candidiasis according to the "Invasive Fungal Infection Group of the European Organization for Research and Treatment of Cancer" criteria. Center B versus Center A, SOFA score on the day of invasive candidiasis diagnosis, diabetes, end-stage renal disease on hemodialysis, recent neutropenia, active cancer, recent antibiotic therapy, prior antifungal therapy, corticosteroid use, parenteral nutrition, Center B (odds ratio, 4.42; 95% confidence interval, 1.35-14.48; p=0.01), prior antifungal therapy (odds ratio, 4.20; 95% CI, 0.79-22.28; p=0.09) and active cancer (odds ratio, 0.23; 95% confidence interval, 0.04-1.29; p=0.09) were predictors of infection with non-albicans.