Abstract
Xenobiotic-induced injuries are very common to liver as it plays a central role in metabolism and biotransformation of xenobiotics. Liver disorders are very common in todays lifestyle. Medicines obtained from various herbs are most abundantly used to treat liver ailments. Nyctanthes arbortristis is one of well known medicinal plant and many of its part are used to treat different diseases/disorders.
In the present project efforts are made to study the differences in the biological activities of the aqueous and ethanolic extract of the Nyctanthes arbortristis leaves using the liver slice model. To study the biological activity and cytoprotective potency associated with the Nyctanthes arbortristis leaf extract CCl4 toxicity model was used. Rat liver slices were incubated in vitro in presence of CCl4 and Nyctanthes arbortristis aqueous and ethanolic leaf extracts for one, two and three hours. The leakage of liver specific enzymes that is aspartate transaminase and alanine transaminase was assessed in the medium. After statistical analysis of the data showed that the leaves of Nyctanthes arbortristis possess hepatoprotective activity however some differences were noted in the activities of aqueous and ethanolic extract mediated protective efficacy.