Abstract
The main objective of this work was to use the Differential Scanning Calorimetry (DSC) and FTIR spectroscopy to study the possible drug-drug or drug-excipient(s) interaction in case of concomitant oral administration of ibuprofen with the most common used antibiotics for children. Amoxicillin, azithromycin, cefuroxime axetil and their commercially available suspensions, Amoxil (R), Azithromax (R) and Zinnat (R) were used. DSC curves for ibuprofen. pure antibiotics, commercially available antibiotics and all binary mixtures used in this study showed drug-drug or drug-excipient(s) interaction and indicate a possible chemical interaction. To confirm chemical drug-drug or drug-excipient(s) interaction additional ATR-IR spectra for all samples used in this study were obtained. Chemical interaction in solid state (drug-drug interaction) was observed by FTIR between cefuroxime axetil and ibuprofen in the binary mixture cefuroxime axetil / ibuprofen (I : I, w/w). Also a chemical interaction in solid state (drug-excipients interaction) was observed in Zinnat suspension (between cefuroxime and excipients), Azithromax (R) suspension (between azithromycin and excipients) and mixture of Azithromax (R)-ibuprofen (between ibuprofen and excipients). From this study it can be concluded that the concomitant oral administration of ibuprofen with commercially available antibiotics used in this study in not recommended and duration of two hours between the oral administrations of these drugs is strongly recommended to avoid drug-drug or drug-excipient(s) interaction.