Abstract
A hybrid pharmacophore approach was adopted to design and synthesize new series of pyrimidine-thiazole hybrid compounds via heterocyclization of 2-(2-guanidino-4-oxo-4,5-dihydrothiazol-5-yl)acetic acid with dicarbonyl compounds, such as diketones and derivatives of acetoacetic ester. The structures of the compounds were established by IR, H-1 NMR, C-13 NMR. The products were obtained in a good yield, short time and a simple experimental procedure. The synthesized compounds were evaluated for their anti-bacterial activity against Grampositive and Gram-negative bacteria. The compounds exhibited excellent zone of inhibition against tested bacteria. The investigation of antifungal screening data revealed that all the tested compounds showed moderate to good fungal inhibition.