Abstract
There is insufficient data to definitively establish the link between coronavirus disease 2019 and asthma, despite reports that individuals with comorbidities are more likely to experience unfavorable clinical outcomes. On account of this, the objective of this study is to carefully analyze the clinical traits of asthmatic COVID-19 patients. 18 COVID-19 patients with asthma and 101 COVID-19 patients without asthma were statistically matched in this single center, retrospective and observational cohort study using propensity scores based on age, sex and comorbidities. In the meantime, data on demographic variables, clinical and laboratory tests and results were gathered and compared between the two groups to identify any differences. According to statistics, patients on the COVID-19 who had asthma had a higher proportion of ICU admissions than those who did not. Additionally, asthma patients showed greater levels of inflammatory responses such as interleukin 6, interleukin 8, procalcitonin, leukocytes, neutrophils, and CD4+ T cells. Additionally, COVID-19 patients with asthma had more significant increases in organ damage markers such D-dimer, lactate dehydrogenase and high sensitivity cardiac troponin I. In COVID-19 asthma patients, exacerbated inflammatory responses and numerous organ damages were induced, highlighting the need for excessive intense surveillance and supportive care.