Abstract
In our previous work, some of thienopyrimidine, benzoxazine, quinazoline and azole moieties 1-18 were synthesized before. We herein report the calcium channel blocking and anti-arrhythmic activities. Nineteen of these compounds were screened for their calcium channel blocking and anti-arrhythmic activities using of Nifedipine as the reference drug. The newly synthesized compounds showed potent calcium channel blocking and anti-arrhythmic activities with low toxicity (LD50) comparable to Nifedipine as reference drug.