Abstract
Wound is a break or discontinuity in the skin or other organs instigated by either surgical procedure or by other means, whereas wound healing is the restoration of lost parts by tissue repairs and regeneration, if not addressed on time; it can lead severe infection, chronic wounds and even death. Current therapeutic options for wound healing stills a universal health challenge. Synthetic or current antimicrobial drugs are expensive, inadequate for the treatment and produce many clinical side effects. Herbal plants naturally promote wound healing however, the mechanisms underlying the wound healing process and related therapies is still in its infancy. Calotropis are perennial shrub belong to plants of the genus Asclepiadaceae used in traditional medicine. Calotropis gigantea Linn (Cg) and Calotropis procera (Cp) are two prominent members with varied pharmacological activities for the treatment for various ailments. The pharmacological activity of their various extracts has been widely studied, revealing, among others its roots and barks used as anticancer, anti-fertility, the antidote for snakebite, anti-scabietic and other parts extracts used to treat skin infections, inflammation and cardiovascular problems. Despite having many experimental supports to attract more pharmacological interest towards this genus, additional investigations are necessary in many areas for its therapeutic options. The current ample review aims at evaluating the merits and the wound healing potential of the phytocompounds obtained from various parts of Calotropis plants and their molecular role in the healing process and provide the platform for bringing to the limelight recent efforts in this efficacious multifaceted medicinal herb.