Abstract
The construction and performance characteristics of selegiline (Sel) carbon paste (CPEs) and plastic membranes electrodes are described. The cited electrodes are based on the ion associates selegiline phosphomolybdate (Sel-PMA) or phosphotungstate (Sel-PTA). Matrix composition of each electrode is optimized on the basis of effects of type and concentration of the ionophore as well as influence of the selected plasticizers. Carbon nanotubes (CNTs) have a good conductivity which helps the transduction of the signal in carbon paste electrode, so the addition small quantity of multi-wall carbon nanotubes (MWCNTs) particles to the composition of carbon paste electrode gave a better performance characteristics for Sel-electrodes with Nernstion slope of 59.50 and 58.20 mV at 25 degrees C for Sel-PMA and Sel-PTA ion associates, respectively within a linear concentration range from 1.0x10(-5) to 1.0x10(-2) M for MWCNTs modified paste electrodes. The mean recovery of the amounts taken of pure and pharmaceutical preparations ranged from 95.2 to 103.5% with RSD = 0.2-0.8%. While for urine and plasma samples, the recovery values ranged from 96.2 to 103.5% with RSD = 0.2-0.7%, with limit of detection (LOD), ranged from 1.52 to 21.26 mu g/L, while the limit of quantification (LOQ) ranged from 1.52 to 20.36 mu g/L for the studied electrodes.