Abstract
Palladium-catalyzed carboxylative Suzuki coupling reactions of benzyl chlorides with allyl pinacolborate were successfully conducted in the absence of any extra ligand to produce β,γ-unsaturated esters in satisfactory to good yields. The carboxylative Suzuki coupling reaction proceeded smoothly under mild conditions in the presence of palladium nanoparticles generated in situ through the formation of a π-benzylpalladium chloride intermediate.
A novel palladium nanoparticles-based catalyst system for carboxylative Suzuki coupling reactions of benzyl chlorides with allyl pinacolborate was developed under mild reaction conditions (low CO2 pressure and temperature) in the absence of any extra ligands. The catalytic system is generated in situ and can thus avoid cumbersome processes for the preparation of metal nanoparticles.