Abstract
This study aimed to explore the toxic impacts of Gold nanoparticles (GNPs) on oxidative stress and expression of Peroxisome proliferator-activated receptor Gamma (PPAR gamma) and Phosphatase and tensin homolog (PTEN) in cardiac and renal tissues of rats. The potential impact of n-3 polyunsaturated fatty acids (n-3 PUFA) in attenuating GNPs cytotoxicity was also studied. The study comprised four groups (10 rats each), G I control; G II injected with a GNPs for six days; GIII injected with GNPs and co -administered orally with n-3 PUFA as GII; G IV: ingested with n-3 PUFA followed by GNPs as GII. The results showed that either pre or coadministration with n-3 PUFA significantly ameliorated the levels of malondialdehyde superoxide dismutase, PPAR gamma and PTEN expression in both the heart and kidney tissues nearly to their normal levels. The present data also revealed that pre and co supplementation with n-3 PUFA, markedly ameliorated the alterations in cardiac and kidney. The current biochemical investigations were confirmed by histopathological examination. The present study concluded that n-3 PUFA could ameliorate the cardio and renal cytototoxic effect induced by GNPs. The mechanisms underlying these promising effects could be through increasing PPAR gamma and PTEN expression which ameliorates antioxidant status.