Abstract
Background
. Arthritis is a common condition that co-exists in the elderly population. This condition leads to frequent administration of comorbid analgesics especially non steroidal anti-inflammatory drugs (NSAIDs).
Aim
. To study cardiorenal toxicity of celecoxib versus ibuprofen in arthritic patients.
Subjects and Methods
. Seven hundred ninety-wo arthritic patients were enrolled in the study for 6 months. Three hundred ninety-six patients administered celecoxib 400 mg twice a day; 396 patients administered ibuprofen 300 mg three times a day. Effects measured included investigator-reported hypertension, edema, or congestive heart failure, increases in serum creatinine or reduction in serum creatinine clearance, and changes in serum electrolytes.
Results
. Celecoxib was associated with significant (
P
< .05) lower incidence of hypertension and edema in comparison with ibuprofen. Systolic hypertension occurred significantly less (
P
< .05) with celecoxib compared with ibuprofen. Serum creatinine was significantly increased (
P
< .05) in patients treated with ibuprofen in comparison with celecoxib. Creatinine clearance was significantly lower (
P
< .05) in cases treated with ibuprofen in comparison to celecoxib. Nonsignificant changes in serum body electrolytes occurred.
Conclusion
. The most important finding of this study was the lowering incidence of cardiorenal toxicity of celecoxib in comparison with ibuprofen.